WebMay 15, 2014 · Folic acid synthesis pathway. Prokaryotes and unicellular eukaryotes such as yeasts or Plasmodium are able to synthesize folate de novo via the folic acid synthesis pathway ().The steps of this pathway include: (i) condensation of dihydropteridine pyrophosphate (DHPP) 1 with p-amino benzoic acid (pABA) 2 by dihydropteroate … WebJul 5, 2024 · Dihydropteroate synthase (DHPS) catalyzes the condensation of 6-hydroxymethyl-7,8-dihydropterin pyrophosphate (DHPPP) with p-aminobenzoic acid (pABA) and is a well validated target for anti-malarial and anti-bacterial drugs. However, in recent years its utility as a therapeutic target has diminished considerably due to multiple …
Dihydropteroate synthase DrugBank Online
WebSep 1, 2004 · Crystal structure of mycobacterium tuberculosis 6-hydroxymethyl-7,8-dihydropteroate synthase in complex with pterin monophosphate: new insight into the enzymatic mechanism and sulfa-drug action J. Mol. Biol , 302 ( 2000 ) , pp. 1193 - 1212 WebNov 30, 2010 · The 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) and dihydropteroate synthase (DHPS) enzymes catalyze sequential metabolic reactions in the folate biosynthetic pathway of bacteria and lower eukaryotes. Both enzymes represent validated targets for the development of novel anti-microbial therapies. We report herein … scr.indianrailways.gov.in online application
Crystal Structure of the 6-Hydroxymethyl-7,8-Dihydropterin ...
WebMay 1, 2015 · Protein target information for Dihydropteroate synthase (Escherichia coli K-12). Find diseases associated with this biological target and compounds tested against it in bioassay experiments. ... NCBI Structure. 6.3 AlphaFold Structures. Help. New Window. Highly accurate protein structure prediction with AlphaFold. Nature. 2024 … WebSep 9, 2011 · This enzyme's structure reveals a feature in the substrate binding groove that is different between CbDHFR and human dihydrofolate reductase (hDHFR). We then identified a compound by in silico screening that exploits this binding groove difference, and demonstrated that this compound inhibits CbDHFR with at least 25-fold greater potency … WebNov 30, 2010 · @article{osti_1627435, title = {Crystal Structure of the 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase•Dihydropteroate Synthase Bifunctional Enzyme from Francisella tularensis}, author = {Pemble, Charles W. and Mehta, Perdeep K ... Dihydropteroate synthase (DHPS) is a key enzyme in bacterial folate synthesis and the … scr in education