WebSerine/arginine-rich splicing factor 1 also known as alternative splicing factor 1 , pre-mRNA-splicing factor SF2 or ASF1/SF2 is a protein that in humans is encoded by the SRSF1 … Serine/arginine-rich splicing factor 1 (SRSF1) also known as alternative splicing factor 1 (ASF1), pre-mRNA-splicing factor SF2 (SF2) or ASF1/SF2 is a protein that in humans is encoded by the SRSF1 gene. ASF/SF2 is an essential sequence specific splicing factor involved in pre-mRNA splicing. SRSF1 is the gene … See more ASF/SF2 is an SR protein, and as such, contains two functional modules: an arginine-serine rich region (RS domain), where the bulk of ASF/SF2 regulation takes place, and two RNA recognition motifs (RRMs), … See more ASF/SF2 is an integral part of numerous components of the splicing process. ASF/SF2 is required for 5’ splice site cleavage and selection, and is capable of discriminating … See more ASF/SF2 has the ability to be phosphorylated at the serines in its RS domain by the SR specific protein kinase, SRPK1. SRPK1 and ASF/SF2 form an unusually stable complex of apparent Kd of 50nM. SRPK1 selectively phosphorylates up to twelve serines … See more SFRS1 is a proto-oncogene, and thus ASF/SF2 can act as an oncoprotein; it can alter the splicing patterns of crucial cell cycle regulatory genes and suppressor genes. ASF/SF2 controls the splicing of various tumor suppressor genes, kinases, and See more ASF/SF2, in the presence of elF4E, promotes the initiation of translation of ribosome-bound mRNA by suppressing the activity of 4E-BP and recruiting molecules for … See more Stability and fidelity ASF/SF2 is involved in genomic stability; it is thought that RNA Polymerase recruits ASF/SF2 to nascent RNA transcripts to impede formation of mutagenic DNA:RNA hybrid R-loop structures between the transcript and the … See more ASF/SF2 has been shown to interact with: • CDC5L, • CLK1, • PSIP1, • SFRS2, • SRPK1, • SRPK2, See more

UniProt

WebResearch has found that serine and arginine rich splicing factor 1 is a key target for neuroprotection, showing its promising potential use in therapeutics for … Web21 Mar 2024 · SRSF6 (Serine And Arginine Rich Splicing Factor 6) is a Protein Coding gene. Diseases associated with SRSF6 include Plasmodium Malariae Malaria and Takayasu … exchange rate rand

Cancers Free Full-Text SRSF5 Regulates the Expression of BQ323636.1 …

Web10 hours ago · Serine/arginine repetitive matrix protein 2, (SRRM2, also known as SRm300, gene name SRRM2 ), a component of spliceosomal complexes 28, 29 and SON, an mRNA binding protein and splicing... Web1 Mar 2015 · SR proteins are essential splicing factors that are regulated through multisite phosphorylation of their RS (arginine/serine-rich) domains by two major families of protein kinases. The... Web30 Sep 2010 · Andrea Barta, Maria Kalyna, Anireddy S.N. Reddy, Implementing a Rational and Consistent Nomenclature for Serine/Arginine-Rich Protein Splicing Factors (SR Proteins) … exchange rate rbi as on 31st march 2021