Splet01. jan. 2010 · Treatment After labeling with BrdU, TPZ and HMTA dissolved in physiological saline were administered at doses of 0.224 mmol/kg or 28.5 mmol/kg, respectively, by single intraperitoneal injection or by continuous administration for 24 h by means of subcutaneously implanted mini-osmotic pumps. SpletThus, the augmented cell death signaling in TPZ + PDT- treated A431 cells appeared to circumvent the p53-MPT route, whereas cell death and growth arrest in Sk-Cha1 cells may have proceeded...
Hypoxia-activated cytotoxic agent tirapazamine enhances hepatic …
Splet15. jul. 2000 · Tirapazamine (TPZ) is a bioreductive drug that exhibits greatly enhanced cytotoxicity in hypoxic tumor cells, which are frequently radiation-resistant and … SpletOrganic and inorganic nanomedicine for combination cancer therapies. Donghyun Lee† a, Jeongsu Shin† a, Hangyu Son a, Seo Young Cheon a, Yeeun Lee a, Joonhyuck Park * a and Heebeom Koo * ab a Department of Medical Life Sciences and Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, 222 Banpo … humber integrated paediatric services
Tirapazamine encapsulated hyaluronic acid nanomicelles realized ...
Splet01. avg. 2024 · In order to remedy the self-limiting hypoxic dilemma of photodynamic therapy (PDT), herein, a facile photosensitizer ( i.e., chlorin e6, Ce6) and bioreductive … Splet12. apr. 2024 · The results indicated that GNPs-TPZ was a potential nanomedicine for selectively targeting hypoxia tumors coupled with decreased side effects on healthy … Splet15. sep. 2024 · Treatment with NTP+TPZ increases gene expression in the apoptotic pathway and oxidative stress while decreasing genes related to cell migration. Immune … hollow steel section sizes